Why has there been an increase in food allergies?

November 10, 2016

There has been a significant increase in the prevalence of food allergy over the past three decades. This has particularly been the case with peanut allergy, which now affects approximately 1% of the general population.1 A diagnosis of food allergy carries with it important nutritional implications, an undeniable impact on quality of life, and increased health care costs.2-4 As researchers look to improve the management of food allergy beyond avoidance and treatment of accidental ingestions with epinephrine, there is also focus on understanding the increase in food allergy over the past several decades.

The rise in food allergy mirrors the increase in other allergic conditions, namely atopic dermatitis (eczema), asthma, and allergic rhinitis (hay fever). The increase in these conditions undoubtedly stems from a complicated interplay between a person’s genetic makeup (genotype) and their interaction with the environment (phenotype). The risk of having a food allergy significantly increases if a first degree relative has a food allergy. Beyond genetics, numerous environmental influences may also play a role.

The roles of breastfeeding, Cesarean sections, diet during pregnancy, and Vitamin D in the development of food allergy are being studied, but there are no definitive conclusions regarding these factors to date. Impaired skin barrier, as seen in eczema, appears to increase the likelihood of developing food allergy.5 Of all the factors studied to date, the two most commonly accepted reasons for the increase in food allergy are the timing of food introduction and the hygiene hypothesis.

Allergic conditions, including food allergy, are more prevalent in urban and first world environments than in rural and third world countries. One of the conspicuous differences between these settings is the level of sanitation and risk of infectious disease. Early life exposures to bacterial, viral, and parasitic infections, along with exposure to a diverse population of normal microorganisms of the human body, are likely to influence the development of the human immune system. The hygiene hypothesis postulates that improved hygiene results in less exposure to microbes, which then leads to an increase in allergic conditions. Children raised on a farm, for example, have lower rates of allergic conditions as compared to children raised in an urban setting.6 In overly simplistic terms, the immune system becomes “bored” by its lack of exposure to microbes, and it subsequently overreacts when exposed to benign stimuli, such as food. Although there is a lot of research supporting the role of hygiene and microorganisms in the increase in allergic disease, including food allergy, it is highly likely that there are other factors involved as well.

The development of food allergy requires previous exposure to the food, which is known as sensitization. Therefore, as food allergy began to increase over the last three decades, particularly in children, guidelines proposed delaying the introduction of highly allergenic foods (i.e., no peanut until three years of age). Despite this recommendation, food allergy continued to increase, and new research showed that delaying the introduction of highly allergenic foods probably increased, not decreased, the risk of food allergy. In February 2015, the Learning Early About Peanut Allergy (LEAP) study demonstrated that the introduction of peanut between 4-11 months of age in a high risk population dramatically decreased the risk of developing peanut allergy compared to late introduction at five years of age.7 This landmark study, along with numerous other similar studies supporting the same concept, has led to a reversal in food allergy guidelines. Although the most updated guidelines are yet to be formalized, the current thinking suggests that early introduction of highly allergenic foods likely decreases the risk of developing food allergy. The timing of food introduction is certainly a key component in developing food allergy, and one over which we have significant control. Nevertheless, the optimal window of opportunity for the introduction of highly allergenic foods remains unclear and is a current area of research focus.

Both genetic and environmental influences play a key role in the development of allergic conditions, including food allergy. Although recent studies have taught us a lot about how to potentially decrease the prevalence of food allergy, there remains much work to be done to prevent this growing public health concern.


1. Sicherer SH, Epidemiology of food allergy. JACI 2011; 127: 594.

2. Christie L, Food allergies in children affect nutrient intake and growth. J of Amer Deit Ass 2002; 102: 11.

3. King, RM. Impact of peanut allergy on quality of life, stress, and anxiety in the family. Allergy 2009; 64: 461.

4. Gupta R. The economic impact of childhood food allergy in the United States. Jama Pedr 2013: 167(11): 1026.

5. Lack G. Update on risk factors for food allergy. JACI 2012; 129: 1187.

6. Alfven T. Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle – the PARSIFAL study. Allergy 2006; 61: 414.

7. Du Toit J. Randomized trial of peanut consumption in infants at risk for peanut allergy. NEJM 2015; 372(9): 803.
Categories: Allergy
Topics: Food Allergy