Neurology Research & Clinical Trials

The Neuroscience Department at Rochester Regional Health is dedicated to providing the highest level of care for its patients. Clinical trials are fundamental for the discovery of new treatments and for developing evidence based medicine, which is considered the best medical care. Participating in clinical trials allows us to offer the latest, cutting edge treatment to our patients and gives them the opportunity to contribute to the improvement of care for future patients. To pursue the goal of developing and providing the highest level of care, our research team is recruiting patients for the listed clinical multi-center trials.

Active clinical trials

Principal Investigator: Kelly Matmati, M.Sc., MD

  1. POINT

    The purpose of this study is to determine the safety and effectiveness of the combination of low-dose aspirin and a medication called clopidogrel (also known by the brand name Plavix®) in reducing the risk of stroke, heart attacks and other complications in patients who have just had a TIA or minor ischemic stroke. Patients who have had a TIA have a higher risk of developing a stroke. Recognizing and treating TIAs can reduce the risk of a stroke. Both aspirin and clopidogrel, medications that prevent blood clots from forming, when used alone, have been shown to be effective in preventing strokes. Several studies that tested the combination of clopidogrel and aspirin have suggested that taking these two medications together may protect patients even more from major stroke and heart attack after a TIA or minor stroke, in comparison to taking aspirin alone, but these studies were small and the risk of bleeding was increased. The POINT trial has been designed to find out whether the combination of aspirin and clopidogrel reduces the risk of stroke, heart attacks and other complications compared to aspirin alone.

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    An intracerebral hemorrhage (ICH) is a hemorrhagic stroke that is caused by bleeding from a blood vessel in the brain. Intracerebral hemorrhages have a high risk of death and disability and expansion of the hemorrhage is predictive of a poorer outcome. The purpose of this study is to find out if there is a benefit to reducing systolic blood pressure (SBP) in a more intensive way (keeping SBP less than 140 mmHg) compared with standard SBP treatment (keeping SBP less than 180 mmHg). This study uses an FDA approved drug called nicardipine to reduce the blood pressure after ICH. Reducing blood pressure in the early stages of ICH is thought to limit the amount of brain damage that occurs. Less brain damage may reduce the high levels of death and disability commonly found in this form of stroke. The primary way the study team will measure if intensive SBP treatment is better than standard SBP treatment is by following the patient’s stroke recovery for 90 days.

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